A podcast about the body's defenders against disease.
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Awesome summary of the immune system Cover art photo provided by Patrick Hendry on Unsplash: https://unsplash.com/@worldsbetweenlines
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Discussing all types of diabetes with various people in the diabetes community including diabetics, diabetic athletes, medical professionals who specialise in diabetes and companies and organisations who work in the diabetes industry.
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Untangling PANDAS & PANS: Conversations about Infection-Associated, Immune-Mediated Neuropsychiatric Disorders
Susan Newman Manfull, PhD
Hello and welcome to Untangling PANDAS & PANS, a podcast about two relatively unknown medical disorders characterized by the sudden and dramatic onset of obsessions and compulsions, vocal or motor tics, or restricted eating behavior -- and a whole host of other symptoms -- following strep or other bacterial or viral infection. Sometimes overnight. I have the privilege of interviewing some of the top researchers and clinicians in the rapidly growing field of Infection-Associated, Immune-Media ...
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This podcast series introduces i-MPACT, a multifaceted program which aims to improve the care of patients treated with immunotherapy, while providing a better understanding of the pathophysiology associated with immune-related adverse events. Each episode features an interview with a leading expert discussing proactive, longitudinal care, as well as the potential for irAEs following treatment with immunotherapy and current toxicity management strategies.
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The immune system is extremely vital for the proper functioning of our body, and important as it is, it also remains somewhat of an enigma to many of us, scientists included. With this podcast, I try to throw some light on this topic, though I must say I’m no expert authority on it, in fact quite far from it, I’m just as clueless as anyone else.
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A monthly podcast with a focus on the use and application of T and B cell receptor repertoires in diagnostics and other clinical settings.
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Become a Paid Subscriber: https://podcasters.spotify.com/pod/show/evelyn-eve4/subscribe Become a Paid Subscriber: https://anchor.fmevelyn-eve4/subscribe Become a Paid Subscriber: https://anchor.fm/evelyn-eve4/subscribe Become a Paid Subscriber: Support this podcast: https://podcasters.spotify.com/pod/show/evelyn-eve4/support
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Immune 86: Where did the SARS-CoV-2 antibodies go?
1:05:13
1:05:13
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1:05:13
Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple…
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S1 E8: Dr. Pawel Kiela Discusses the Gut Microbiome, Microglia, and PANDAS
1:19:01
1:19:01
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1:19:01
Pawel Kiela, DVM, PhD currently holds the rank of Professor and has a PANDA endowed chair in Autoimmune Disease Research in the Department of Pediatrics at the University of Arizona Medical School in Tucson. Dr. Kiela is an integral part of the Steele Children’s Research Center which has four integrated branches: basic science, clinical research, c…
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Immune 85: Immune trade-offs
1:11:57
1:11:57
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1:11:57
Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patro…
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S1 E7: Dr. Tim Ubhi Talks about Treating PANDAS/PANS in the UK at his new London PANS Clinic
1:25:58
1:25:58
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1:25:58
Susan Manfull, PhD crossed the pond to speak with Dr. Tim Ubhi, consultant paediatrician and fellow of the United Kingdom’s Royal College of Paediatrics and Child Health. Dr. Tim, as his patients call him, has dedicated his life to children’s health, beginning with conducting research on using botulinum toxin to help children with cerebral palsy, w…
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Immune 84: Gender-affirming therapy and immune responses with Petter Brodin
1:04:50
1:04:50
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1:04:50
Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men). Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Guest: Petter Brodin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for …
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Immune Booster #9: Autoimmune diseases with Mark Shlomchik
25:05
25:05
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25:05
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. Hosts: Cindy Leifer and Steph Langel Guest: Mark Shlomchik Subscribe (free): Apple Pod…
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Immune Booster #8: Immunology, metabolism, and exercise physiology with Heather Caslin
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26:42
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26:42
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease. Hosts: Cindy Leifer and Brianne Barker Guest: Heather Caslin Subscribe (free): Apple Podcast…
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Immune 83: Immune cells eating other cells
1:23:37
1:23:37
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1:23:37
Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patro…
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S1 E6: The Story Behind AB2105, California's Bill to Require Insurance Coverage for PANDAS/PANS Treatment
50:49
50:49
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50:49
In this episode of Untangling PANDAS & PANS, Susan Manfull, PhD talks with April Ronay, founder of California Coalition for PANS/PANDAS (aka, Cal-Coalition), and Shari Strulson, one of the founding members of Cal-Coalition. Both are teachers, by profession, both have a family member with PANS, and both are tirelessly working to pass legislation in …
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Immune Booster #7: Emerging viruses with David Martinez
23:46
23:46
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23:46
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey. Hosts: Cindy Leifer and Steph Langel Guest: David Martinez Subscribe (f…
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Immune Booster #6: From Ghana to heat shock with Robert Binder
27:29
27:29
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27:29
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science. Hosts: Cindy Leifer an…
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Immune Booster #5: Infections and the gut microbiome with Rafael Polidoro
28:35
28:35
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28:35
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts: Cindy Leifer and Steph Langel Guest: Rafael Polidoro Subscribe (free): …
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i-MPACT Podcast - Ep. 12 - Dr. Mike McCall (Part 2 of 2)
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39:08
In part two of this two-part interview, host Dr. John Walker sits down for a candid conversation with Dr. Mike McCall, MD, PhD, FRCSC, Surgical Oncology and General Surgery at the Royal Alexandra Hospital in Edmonton, Alberta. The i-MPACT Podcast is a series that discusses cutting edge research and treatments related to the immune system’s dynamic …
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i-MPACT Podcast - Ep. 12 - Dr. Mike McCall (Part 1 of 2)
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41:17
In part one of this two-part interview, host Dr. John Walker sits down for a candid conversation with Dr. Mike McCall, MD, PhD, FRCSC, Surgical Oncology and General Surgery at the Royal Alexandra Hospital in Edmonton, Alberta. The i-MPACT Podcast is a series that discusses cutting edge research and treatments related to the immune system’s dynamic …
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Immune 82: Bat antibodies are hot
1:14:58
1:14:58
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1:14:58
Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email…
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S1 E5: Earl Harley, MD Talks About How Otolaryngologists Can Assist in the Treatment of PANDAS
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44:53
Earl Harley, MD, FACS, FAAPS is a highly regarded pediatric otolaryngologist (Ears, Nose, and Throat doctor or ENT) at Georgetown University Medical Center and a beloved assistant professor at the Medical School. Dr. Harley is widely respected for his expertise in working with patients who have been diagnosed with PANDAS and PANS. Families travel f…
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Immune Booster #4: Human autoimmunity with Jane Buckner
19:51
19:51
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19:51
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer and Steph Langel Guest: Jan…
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i-MPACT Podcast - Ep. 11 - Dr. Egiroh Omene
1:09:53
1:09:53
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1:09:53
Dr. John Walker chats with Dr. Egiroh Omene, MD, FRCPC and neuro-oncologist at the Cross Cancer Institute at the University of Alberta. The i-MPACT Podcast is a series that discusses cutting edge research and treatments related to the immune system’s dynamic role in health and disease. It is designed with both health professionals and patients in m…
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Immune Booster #3: NKT cells and cancer, and DEI in research with Tonya Webb
29:01
29:01
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29:01
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research. Hosts: Cindy Leifer and Brianne Barker Guest: Tonya Webb Subscribe (free): Apple Podcasts, RSS, email …
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Immune Booster #2: Sex differences in immune responses with Michal Tal
27:41
27:41
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27:41
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career. Hosts: Cindy Leifer and Brianne Barker Guest: Michal Tal Subscribe (free): Apple Podcasts, R…
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Immune Booster #1: From bench to bedside to beat HIV with Luis Montaner
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25:47
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25:47
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression. Hosts: Cindy Leifer and Brianne Barker Guest: Luis Montaner Subscribe (free): Apple Podcasts, RSS, email…
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S1 E4: Beth Latimer, MD Discusses How the Understanding of PANDAS has Progressed: It is Not Solely a Pediatric Disorder
1:06:31
1:06:31
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M. Elizabeth “Beth” Latimer, MD is a pioneer in the field of autoimmune encephalitis and is known across the country and in Europe for her expertise in treating PANDAS and PANS. She received her medical degree from Tufts University School of Medicine in Boston, Massachusetts. She completed her residencies in Pediatrics and Neurology at Walter Reed …
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Immune 81: T cells and tolerance with Joseph Larkin III
41:23
41:23
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41:23
Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance. Hosts: Stephanie Langel and Brianne Barker Guest: Joseph Larkin III Subscribe (free): Apple Podcast…
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Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes
1:15:56
1:15:56
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1:15:56
Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for thi…
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Immune 79: Spa therapy for the immune system
1:04:21
1:04:21
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1:04:21
Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts: Vincent Racaniello, Cynthia Leifer, and Bria…
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S1 E3 Part 1: What Do Tick-Borne Diseases Have to Do with PANS?
56:36
56:36
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56:36
Dr. Shannon Delaney, a psychiatrist with expertise in PANDAS/PANS, Lyme, and other vector-borne diseases, talks with Susan Manfull about how these complex disorders present in children and adults. Much of what she came to learn about Lyme came from her work with Dr. Brian Fallon at Columbia University. After her residency at Harvard Longwood Psychi…
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S1 E3 Part 2: What Do Tick-Borne Diseases Have to Do with PANS?
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29:33
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29:33
In Part 2, the discussion with Dr. Shannon Delaney continues with a focus on the diagnosis and treatment of Lyme and other tick-borne diseases. Recorded May 13, 2024 Disclaimer: The views and opinions expressed in this program are those of the speakers and do not necessarily reflect the views or positions of any entities they represent. Credits: Mu…
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S1 E3 Part 3: What Do Tick-Borne Diseases Have to Do with PANS?
13:22
13:22
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13:22
In Part 3, the discussion with Dr. Shannon Delaney continues on her soon-to-be-released study in Frontiers in Psychiatry Journal about the prevalence of Bartonella in patients diagnosed with Bartonella. Recorded May 13, 2024 Disclaimer: The views and opinions expressed in this program are those of the speakers and do not necessarily reflect the vie…
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S1 E2: The Intersection of Strep, Intractable OCD, Psoriasis, and IL-17: A Conversation with Kyle Williams, MD, PhD and Andrew
1:06:04
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1:06:04
In episode two, Susan Manfull interviews Dr. Kyle Williams, Director of the Pediatric Neuropsychiatry and Immunology Program at Massachusetts General Hospital, and Andrew about the potential link between strep, psoriasis, psoriatic arthritis, and obsessive-compulsive disorder (OCD). Andrew shares his personal experience of how his psoriasis and OCD…
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S1 E2 Bonus: The Intersection of Strep, Intractable OCD, Psoriasis, and IL-17: Continued conversation with Kyle Williams, MD, PhD and Andrew
15:54
15:54
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15:54
It seemed our conversation from Episode 2 was left dangling so we continued talking. If you would like to hear a wee bit more, listen to this bonus content which captures most of that conversation, mostly musings about navigating the medical system and whether the division between psychiatry and neurology is artificial (another dangling conversatio…
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S1 E1:The Immunological Basis of Eating Disorders and PANDAS/PANS
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50:15
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50:15
Lauren Breithaupt, PhD, Assistant Professor of Psychiatry, based in the Eating Disorders Clinical and Research Program at Massachusetts General Hospital, will discuss her cutting-edge research about the immunological basis of eating disorders and PANDAS and PANS. After briefly describing her work on eating disorders, she talks about her new researc…
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S1 E1 Bonus: PANDAS/PANS Advocacy Day on Capitol Hill - Join us on April 12, 2024
42:32
42:32
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42:32
In this bonus episode, I will be talking about our second annual PANS/PANDAS Advocacy Day on Capitol Hill, a joint event planned by the National Alliance of PANS/PANDAS Action (NAPPA) and The Alex Manfull Fund (TAMF) to be held on Friday, April 12th in Washington, DC. My guests -- Amanda Peel Crowley, co-founder of NAPPA, and Paul J. Murphy, Treasu…
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Immune 78: Tolerance and tolerating many vaccines
1:24:03
1:24:03
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1:24:03
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: V…
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