Cele mai bune Pediatric Research podcast-uri (2024)

1
Senior Investigator: Conversation with Michael DeBaun 16:56

29d ago16:56

16:56

This episode features a conversation with Senior Investigator Michael DeBaun, Professor of Pediatrics and Medicine at Vanderbilt University Medical Center, who has had a long career investigating the causes of and treatments for sickle cell anemia, and advocating for children and adults with this condition across the globe. You can access his Vande…

1
Collection on Fetal Alcohol Spectrum Disorder 17:29

2M ago17:29

17:29

In this episode, Geoff Marsh speaks to Dr. Stephanie Ford about our Collection on Fetal Alcohol Spectrum Disorder. Read the collection here: https://www.nature.com/collections/fccidiefbi Hosted on Acast. See acast.com/privacy for more information.

1
August/Senior Investigator: Conversation with Tina Cheng 12:45

3M ago12:45

12:45

This episode features a conversation with Senior Investigator Tina Cheng, who has held several leadership positions over her career, including her current roles as Chair of Pediatrics at the University of Cincinnati, and Director of the Cincinnati Children’s Research Foundation. Her clinical work and research work have had a long and lasting impact…

1
What's hot in stem cells and regenerative biology? 13:23

4M ago13:23

13:23

Listen to July's Pediapod episode: What's hot in stem cells and regenerative biology? with Atul Malhotra. Hosted on Acast. See acast.com/privacy for more information.

1
June/Senior Investigator: Conversation with Richard Jackson 14:07

5M ago14:07

14:07

This month features a conversation with Senior Investigator, Professor Richard Jackson, who’s had an extensive career in Public Health. Now Professor Emeritus at the Fielding School of Public Health at the University of California, Los Angeles, Richard has served in many leadership positions including nine years as Director of the CDC's National Ce…

1
Collection on neonatal encephalopathy and hypoxic-ischemic encephalopathy 14:21

6M ago14:21

14:21

In this episode, listen to our editorial apprentice, Dr. Eric Peeples describe the scope and importance of our collection on neonatal encephalopathy and hypoxic-ischemic encephalopathy. Visit the collection here: Neonatal Encephalopathy and Hypoxic Ischemic Encephalopathy (nature.com) Hosted on Acast. See acast.com/privacy for more information.…

1
What's hot in Endocrinology? 11:15

7M ago11:15

11:15

In this episode of Pediapod, Section Editor Jeanie Tryggestad discusses the most recent advances in the field of Pediatric Endocrinology. Hosted on Acast. See acast.com/privacy for more information.

1
Conversation With Pediatric Researchers Cynthia Bearer and Eleanor Molloy 13:18

8M ago13:18

13:18

Pediatric researchers Cynthia Bearer and Eleanor Molloy join podcast host Geoff Marsh to give an update on plans for the podcast and to offer some sage advice for Early Career Investigators. Find more Pediapod episodes here: https://www.nature.com/collections/fcbjjbchaa Hosted on Acast. See acast.com/privacy for more information.…

1
Conversation with Linda de Vries 13:43

10M ago13:43

13:43

This episode involves a conversation with senior investigator Linda de Vries, who has had a large and lasting effect in the world of pediatric research. Hosted on Acast. See acast.com/privacy for more information.

1
Global climate change: the defining issue of our time for our children’s health 13:46

11M ago13:46

13:46

The United Nations recently stated that “climate change is the defining issue of our time, and we are at a defining moment” (https://www.un.org/en/global-issues/climate-change). This statement ended the political debate about the role of human activities in climate change. Global climate change is happening and it will have a profound effect on our…

1
Predicting functional and quality-of-life outcomes following pediatric sepsis. 13:24

1y ago13:24

13:24

Illness severity scores are commonly used for mortality prediction and risk stratification in pediatric critical care research. However, as mortality has steadily declined in the pediatric intensive care unit there has been increasing attention given to evaluating non-mortality outcomes in survivors. In this episode we meet Early Career Investigato…

1
Conversation with Dr. Maximo Vento 17:42

1y ago17:42

17:42

This episode, along with a few more to come, involves a conversation with a senior investigator who has had a large and lasting effect in the world of pediatric research. The Early Career Investigator episodes will still be coming once a month, but hopefully this will add a bit of variety to the Pediapod feed and shine a light on some of the pionee…

1
The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy 13:01

1y ago13:01

13:01

Hypoxic Ischaemic Encephalopathy (HIE), a subset of neonatal encephalopathy, is the most common neurological condition in term born infants. It is known that a range of acute and chronic placental pathologies are more common in infants with HIE. However little is known about how differences in utero-placental function might contribute to varied out…

1
Do Bayley trajectories predict school-readiness better than single assessments in formerly very preterm infants? 11:59

1y ago11:59

11:59

The development of children born very preterm is most often evaluated using the Bayley Scales of Infant Development. These single assessments are routinely used as outcome measures for neonatal interventions or as a means of prognosis. However, early Bayley scores may not accurately predict later outcomes. In this episode of Pediapod, we speak to D…

1
Novel metrics to characterise the temporal lobe of very preterm infants. 11:19

1y ago11:19

11:19

The temporal facilitates many complex neurological processes. Alterations to these processes are known to correlate with specific functional deficits commonly found in preterm-born children at and beyond school age. However, as yet there is not an objective, validated method to assess the temporal lobe structure or size in very preterm infants. In …

1
Trends in fetal and neonatal outcomes during the COVID-19 pandemic 12:13

1+ y ago12:13

12:13

The COVID-19 pandemic severely affected health and healthcare systems worldwide and could have resulted in changes in fetal and neonatal outcomes. In this episode, we speak to Early Career Investigator, Vivek Shukla from the University of Alabama at Birmingham. Using machine learning techniques, he performed a population-based study to identify cha…

1
The transition to telemedicine in pediatric primary care during the first year of the COVID-19 pandemic 11:00

1+ y ago11:00

11:00

Before the COVID-19 pandemic, the use of telemedicine was limited in pediatric primary care. Then, in 2020 it increased exponentially. However, early COVID-19 reports described inequities in telemedicine use across multiple specialties. In this episode, we meet Early Career Investigator, Kelsey Schweiberger from the University of Pittsburgh. In a r…

1
Cardiorespiratory signature of neonatal sepsis 12:08

1+ y ago12:08

12:08

Heart rate characteristics and demographic factors have long been used to aid early detection of late-onset sepsis, however respiratory data may contain additional signatures of infection. In this episode we meet Early Career Investigator Brynne Sullivan from the University of Virginia. She and her team developed machine learning models to predict …

1
BMI trajectories and BPD among very preterm infants 10:54

1+ y ago10:54

10:54

Bronchopulmonary dysplasia (BPD) is the most common morbidity among very preterm infants. Commonly, nutritional interventions are focused on achieving optimal body weight gain. However, very preterm infants with evolving lung disease often experience disproportionate growth in the neonatal period, which may contribute to the odds of developing BPD.…

1
March: Cardiovascular outcomes in children with Kawasaki disease 13:03

1+ y ago13:03

13:03

Kawasaki disease is a common childhood vasculitis and its global incidence appears to be increasing. Although this disease is self-limiting, the associated vasculopathy can cause cardiovascular complications. In this episode of Pediapod, we meet Early Career Investigator Cal Robinson at the Hospital for Sick Children, Toronto, Canada who performed …

1
February: Pharamcogenetic profiling in children with medical complexity 12:42

2y ago12:42

12:42

Children with medical complexity typically require multiple medications throughout the course of their treatment. These individuals also increasingly undergo genome-wide testing early in life as a diagnostic test. Since many medications prescribed to children have established gene-drug interactions, could this genetic data be repurposed to aid prec…

1
Sex-specific effects of prenatal opioid exposure 13:18

2y ago13:18

13:18

Neonatal opioid withdrawal syndrome (NOWS) represents a major public health problem in the US with a high socioeconomic burden. The pathophysiology of this condition is not yet fully understood. Data from animal models have shown that opioids modulate brain reward signalling via an inflammatory cascade, however no such data exist for opioid-exposed…

1
Barriers to finding a genetic diagnosis for children with rare disease. 13:46

2y ago13:46

13:46

Rare diseases affect millions of people in the USA. However, access to subspecialty care is not distributed equitably and there may be other barriers to clinic attendance. Furthermore, once established within the genetics clinic, families may still face barriers along the path to getting a molecular diagnosis. In this episode, we meet Early Career …

1
Neutrophil function in pediatric lupus. 10:07

2y ago10:07

10:07

Systemic lupus erythematosus (SLE) causes significant long-term morbidity and mortality, particularly in children. There is some evidence that the innate immune system, in particular neutrophil activity, can be compromised in adult-onset lupus. Yet there is a paucity of data on neutrophil activity in pediatric SLE. This month on Pediapod, we join E…

1
The social epidemiology of adolescent problematic screen use. 14:54

2y ago14:54

14:54

95% of adolescents in the US have access to a smartphone and 45% report being online "almost constantly". Beyond the general time spent on screens, the control over usage and the interference into other activities are also important considerations and could reflect problematic screen use. This week on Pediapod, we meet Early Career Investigator, Pr…

1
How neonatologists' views on the Baby Doe regulations have changed over time. 14:23

2y ago14:23

14:23

The Baby Doe Regulations, which regulate the provision of life-sustaining treatment to seriously ill neonates, caused a stir amongst neonatologists when they were first enacted in the 1980s. The fear at the time was that they would restrict their ability to provide optimal care to seriously ill patients by mandating the use of aggressive treatments…

1
Placental transfusion during neonatal resuscitation in a preterm model 10:20

2+ y ago10:20

10:20

For depressed preterm neonates, initiating positive pressure ventilation is the most important factor in facilitating transition. Therefore the recommendation for depressed neonates is to immediately cut the umbilical cord and begin resuscitation. However, many studies have shown that delaying the clamping of the umbilical cord also benefits preter…

1
Severe intraventricular hemorrhage in a rabbit model of prematurity 11:41

2+ y ago11:41

11:41

Intraventricular hemorrhage (IVH) occurs in around 45% of infants born below 26 weeks gestational age, causing significant lifelong morbidity and mortality. However, there is currently no effective treatment. In part, this is due to the lack of well-characterised representative preterm animal models with long-term follow up. In this episode, we mee…

1
Maternal early exposure to violence, psychopathology, and child adaptive functioning 12:16

2+ y ago12:16

12:16

A recent study reported that 53% of mothers reported exposure to violence when they were children. And there is evidence that these experiences negatively impact the health and development of their offspring later on. Associations between maternal exposure to violence, psychopathology and children's mental health outcomes is well documented. Howeve…

1
April: miRNA expression in the pediatric dilated cardiomyopathy heart 13:33

2+ y ago13:33

13:33

Dilated cardiomyopathy (DCM) is a rare but serious condition of children and often progresses to heart failure. The outcomes for children with DCM are poor, with 50% of pediatric patients dying or needing a heart transplant within 5 years of diagnosis. In this episode, Geoff Marsh meets professor Carmen Sucharov from the University of Colorado Ansc…

1
The fetal immune response to maternal SARS-CoV-2 infection 11:31

2+ y ago11:31

11:31

Thousands of women have been infected with SARS-CoV2 during the COVID-19 pandemic. While very few of these infections have been shown to transmit vertically from mother to offspring, it remains unclear what effect, if any, a mother's SARS-CoV2 infection has on fetal development. In this episode, we interview Dr Brian Kalish from the University of T…

1
Whole-exome sequencing of epilepsy after acute symptomatic neonatal seizures 11:09

3y ago11:09

11:09

Twenty-five percent of children who survive acute symptomatic seizures as neonates go on to develop epilepsy. Whilst there are several known risk factors, currently not enough is known about the mechanisms behind the development of epilepsy following neonatal brain injury, and thus it is not yet possible to reliably predict the individual risk of d…

1
New technique for estimating respiratory rates in preterm infants 11:08

3y ago11:08

11:08

Most very preterm infants experience apneas of prematurity. It is a common comorbidity of prematurity, and therefore reliable real-time monitoring of respiratory rates is key in these infants. The conventionalmethod is to use chest impedance measured with electrodes on the surface of the thorax. However, this method is known to be unreliable, as it…

1
Associations of media use and early childhood development: cross-sectional findings from the LIFE Child study 13:14

3y ago13:14

13:14

There is a growing body of evidence showing that excessive early media use is detrimental to children's physical and mental health. As such, the World Health Organization guidelines suggest that screen time for infants should be limited to a maximum of one hour per day. However, with the growing ubiquity of digital media, it is thought that prescho…

1
Early Career Investigator Spotlight: Matthew W. Harer 11:15

3y ago11:15

11:15

Caffeine administration has been associated with reduced rates of Acute Kidney Injury (AKI) in preterm neonates but the effect of caffeine on renal oxygenation is unknown. In this episode, we meet this month's highlighted Early Career Investigator, Dr. Matthew Harer from the University of Wisconsin School of Medicine and Public Health. He has been …

1
SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges 10:49

3y ago10:49

10:49

Early on in the SARS-CoV-2 pandemic, the majority of infected children were either asymptomatic or had mild COVID-19 disease, prompting many to demand a higher acceptable risk threshold for pediatric vaccines. More recently, as children begin to make up a larger proportion of the infected population and following evidence of the mental and physical…

1
Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes 9:58

3y ago9:58

9:58

Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory joint diseases in children. Previous studies have shown that in the oligoarticular subtype of this disease, T cells play a central role in pathogenesis. T cell inhibitory receptors (IRs) seem to play an important role in the development of tolerance and recognition of self a…

1
Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero 15:45

3+ y ago15:45

15:45

Chorioamnionitis is an intrauterine infection of the placenta and fetal membranes. It is the leading cause of preterm delivery and is a common risk factor for adverse pulmonary outcomes such as bronchopulmonary dysplasia. There is evidence to suggest that the first negative impacts on pulmonary development occur in utero in the presence of chorioam…

1
Marc Beltempo – Early Career Investigator Highlight 11:49

3+ y ago11:49

11:49

Previous studies have shown an association between fluid retention during the early postnatal period and increased BPD. However, these studies were performed nearly two decades ago meaning their results may not apply to the contemporary NICU setting, with its widespread use of surfactants and modern incubators. In this episode we meet this month's …

1
Calcium-sensing receptor and CPAP-induced neonatal airway hyper reactivity in mice 10:38

3+ y ago10:38

10:38

Respiratory support plays a crucial role in the care of preterm infants in the NICU, ensuring that they get enough oxygen during this critical period of development. But it is becoming increasingly clear that former preterm infants who have been exposed to ventilatory support are at an increased risk of developing asthma and other respiratory disor…

1
The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker 12:54

3+ y ago12:54

12:54

Extremely preterm infants are at a high risk for brain injury, and this risk is most severe in children with intraventricular hemorrhage followed by post-hemorrhagic ventricular dilation. Bedside cranial ultrasound allows clinicians to identify the progressive dilation of the lateral ventricles, however, there is currently no consensus on how to qu…

1
Impact of integrated clinical decision support systems in the management of pediatric acute kidney injury: a pilot study 11:13

3+ y ago11:13

11:13

Acute kidney injury (AKI) causes significant morbidity and mortality in children, including prolonged hospital stays, increased risk of in-hospital death and future risk of hypertension and progression to chronic kidney disease. Whilst it is quite common, it often goes unrecognized, especially outside of the critical care setting. In this episode, …

1
Autonomic development in preterm infants is associated with morbidity of prematurity 11:38

4y ago11:38

11:38

The latter half of gestation and early neonatal life are critical periods for the maturation of the autonomic nervous system. Premature infants are born with underdeveloped autonomic maturation and must undergo their developmental changes in a vastly different setting to the natural, in utero environment. A number of studies have shown autonomic dy…

1
Early pediatric chronic kidney disease is associated with brain volumetric gray matter abnormalities 11:00

4y ago11:00

11:00

Pediatric chronic kidney disease (pCKD) results in a life-long burden that requires routine care. Neurocognitive dysfunction, specifically impairment on tasks of executive function, is a well-established comorbidity but there is a paucity of data exploring the neurobiology of these cognitive deficits. In this episode, we meet early career investiga…

1
Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future 10:56

4y ago10:56

10:56

Therapeutic Hypothermia has long been the standard of care for infants with moderate to severe neonatal encephalopathy. However, the future of treatment for neonatal encephalopathy (NE) will focus on hypothermia adjuvant therapies. There needs to be a rethink in how future NE clinical trials are designed and analyzed, according to a multi-disciplin…

1
Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival 11:35

4y ago11:35

11:35

Pediatric Pulmonary hypertension (PAH) is a heterogeneous disease, characterized by sustained elevation of pulmonary arterial pressures and death from right ventricular failure. Given the extremely high burden of morbidity and mortality associated with this disease, and the risk of the invasive procedures required for diagnostics, novel biomarkers …

1
Rapid exome sequencing in PICU patients with new-onset metabolic or neurological disorders. 12:19

4y ago12:19

12:19

Effective decision making in the Pediatric Intensive Care Unit relies on quickly ascertaining diagnostic information in order to deliver a tailored clinical response. The utility of rapid genetic testing of critically ill patients has been demonstrated several times, owing to their relatively high diagnostic yield. However the cost and slow turnaro…

1
Child tobacco smoke exposure and healthcare resource utilization patterns. 11:11

4y ago11:11

11:11

Smoking in adults and adolescents is at an all-time low today, yet around 1 in 2 children who visit the Emergency Department have been exposed to tobacco smoke. We know that there numerous health consequences associated with tobacco smoke exposure (TSE), and that this also comes at a substantial monetary cost- in 2010, child tobacco smoke exposure …

1
A pilot study exploring interventions for physician distress in pediatric subspecialists. 13:33

4+ y ago13:33

13:33

Institutions and healthcare systems had started to introduce wellness initiatives following the growing realization of the widespread problem of physician distress and burnout. Whilst these programs might be effective, there is currently a lack of evidence about who uses them and whether they are best suited to their target audience. In this episod…

1
Continuous glucose monitoring profile during therapeutic hypothermia in encephalopathic infants with unfavorable outcome 11:08

4+ y ago11:08

11:08

40% of infants with hypoxic ischemic encephalopathy (HIE) go on to develop long-term disability, despite receiving therapeutic hypothermia. Mounting evidence suggests that children with HIE are at a higher risk of both hypoglycemia and hyperglycemia, which may explain the variable outcomes to therapeutic hypothermia. In this episode, we meet this m…

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