Personalized Medicine podcast

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Episode Notes [01:14] Unexpected Email from Employer [05:49] The Deferred Resignation Program [06:34] Initial Reactions and Concerns [08:01] Evaluating the Offer [08:21] Enhanced Standards of Conduct [08:55] Personal Reflections and Concerns [12:21] Seeking Advice and Making a Decision [13:01] Option One: Do Not Resign [14:56] Option Two: Resign [16:44] Insights from Conversations [21:30] Making The Decision [23:51] Final Thoughts and Gratitude Resources Mentioned Sebastian Junger The Soul of Shame by Curt Thompson Donald Trump Elon Musk Steve Bannon Russell Vought Derek Sivers Sumner Crenshaw Brian Fretwell at Finding Good Chad Littlefield The Thought Leaders Practice by Matt Church Simon Cowell Beauty Pill Producer Ben Ford Questions Asked Is it legitimate, and can it be trusted? How are you feeling? What questions come to your mind? Where does your mind go? Are you seeking safety? Would this have been an adrenaline rush as you raced to send the resignation response? What an "enhanced standard" regarding loyalty and trustworthiness was? What are these new "enhanced standards?" Are they beyond what my Constitutional oath requires? If I don't resign, how bright will the target on my back glow? My leadership has supported all my work, but would termination direction come from higher up the chain of command? What would you recommend if we talked over coffee? What questions would you ask? How would you use listening? How would you use silence? How is this scenario playing out in your mind and body? What is coming to the surface for you? How might that influence what you are about to say to me? What are the chances of my name popping on a list and getting fired? How about the chances of being part of an official Reduction in Force and early retirement? Would the administration make a better offer? What do I know about the pending job market? What did I expect the workplace to be like and did I want to be there as the contractions took place? Will the administration pay me through the end of September or will they renege? Can I sufficiently build the Curated Questions business to transition by 1 October? - Do I have the faith or confidence to step into this future as a sole practitioner and grow Curated Questions into all I envisioned? Was this purpose calling? What would I expect the job market to look like at the end of summer if I hadn't developed the income streams to maintain our lifestyle? What is your recommendation? Did it change from your initial recommendation? Where in your body are you feeling the uncertainty? Are you processing this scenario in parallel with your decision as if you had received the email? What additional questions should I have considered? Who else should I have consulted with? How would you have changed my risk rating? What is the correct length of the pregnant pause before making an important announcement? What processes would you use in my circumstance, and what would be different? What questions are at the top of your list to get to a decision? Who would be the members of your pantheon you would counsel with to gain clarity? Apart from the heady analysis, what other key practices would you include in your journey through a similar situation?…

Personalized Medicine Podcast

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On this podcast leading scientist, clinicians and entrepreneurs share their thoughts on the progress of personalized medicine. With our guests, we discuss new technologies for targeted treatments and diagnostics, their benefits for patients and clinicians and related implementation challenges.

48 episoade

Personalized Medicine Podcast

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updated acum 2 ani

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48 episoade

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Personalized Medicine Podcast

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Ep#47: Podcast Finale 27:55

acum 2 years27:55

27:55

Dear listeners, This is a bittersweet moment for us. With this episode, we conclude the Personalized Medicine Podcast series. We would like to thank all of you for staying with us over the last 3 years! This has been an amazing ride and we appreciate your constant support and feedback. We hope you enjoyed listening to this show as much as we enjoyed making it for you. In this final episode, our team sits down once more to remember how it all started and how the team came together over these years. We share our most memorable podcast moments and words of gratitude to our guests and listeners. Thank you so much for being with us on this journey! Stay tuned for our next projects. Sincerely yours, Oleksandr (aka Sasha), Luisa, Aradhana, Ivana, Ting and Mehar…

Personalized Medicine Podcast

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Ep#46: Improving Healthy Longevity via Transcription Factors with Dr. Victor Bustos 31:19

acum 2 years31:19

31:19

In this episode of the Personalized Medicine Podcast we sat down with Dr. Victor Bustos, the co-founder and COO of Refoxy Pharma, a pharmaceutical company focused on new therapies for age-related diseases. Victor is a molecular biologist by training and dedicated his research career to understanding the biology of aging. In this interview, we discuss the role of FOXO transcription factors in regulating lifespan, Victor's transition from academia to the world of biotech start-ups and his progress with Refoxy Pharma.…

Personalized Medicine Podcast

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Ep#45: Applying DNA Nanostructures to Personalized Medicine with Dr. Ali Aghebat Rafat 38:58

acum 3 years38:58

38:58

Welcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana sat down for a conversation with Dr Ali Aghebat Rafat, Scientist at Tilibit Nanosystems. Aradhana and Ali discussed DNA nanostructures, DNA self-assembly, barcoding, biochips and their potential applications in Personalized Medicine. Tune in to this episode to learn more about: ◦ Tilibit Nanosystems and their mission ◦ Application areas of DNA origami in diagnostics ◦ What is DNA Paint ◦ A day in a life of a start-up scientist ◦ Role of nucleic acid nanostructures in Personalized Medicine ◦ The outlook on the future of DNA origami technology…

Personalized Medicine Podcast

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Ep#044: Applying Nanoparticles and Microfluidics to Personalized Medicine with Martin Rabel 48:58

acum 3 years48:58

48:58

Welcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana talked to Martin Rabel, the Field Application Scientist at Precision Nanosystems, about nanoparticles, microfluidics, gene delivery in the context of personalized medicine. Tune in to this episode to learn more about: ◦ Precision Nanosystems and their mission ◦ Role of nanoparticles and microfluidics in Personalized Medicine ◦ Next-Gen microfluidics technologies ◦ Application of nanoparticles in pharmaceutical applications ◦ Challenges in developing RNA-based lipid nanoparticles ◦ Role of regulatory bodies in implementation of personalized medicine approaches ◦ The outlook on the future of personalized medicine Get in touch with Martin: ◦ LinkedIn: Martin Rabel ◦ Twitter: @rabel_martin…

Personalized Medicine Podcast

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Ep#043: Developing Precision Medicines Using Cryo-EM with Dr. Sriram Subramaniam 43:23

acum 3 years43:23

43:23

In this episode we dive deep into the world of structural biology. We discuss the role of cryogenic electron microscopy in the development of precision medicines with the founder and CEO of Gandeeva Therapeutics, Dr. Sriram Subramaniam. Cryo-EM opened a new way to study drug-target interactions and is changing the way we develop new therapies. Tune into our interview with Sriram to learn more about: ◦ The founding story of Gandeeva Therapeutics ◦ The evolution of Cryo-EM technology ◦ Application of Cryo-EM in drug discovery ◦ Advantages of Cryo-EM over crystallography im mapping protein structures ◦ Making sense of experimental data with AI and machine learning ◦ The future of personalized medicine and role of structural biology in it ◦ Sriram’s advice for budding life science entrepreneurs…

Personalized Medicine Podcast

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Ep#042: Applying Epigenetics to Personalized Skincare with Dr. Shakiba Kaveh and Dr. Cristiana Banila 32:51

acum 3 years32:51

32:51

In this next podcast episode we dive into a topic of personalized skincare. Our host Oleksandr is joined by the co-founders of Mitra Bio, Dr. Shakiba Kaveh and Dr. Cristiana Banila. Pharmaceutical and personal care companies have been trying to unlock personalized skincare for decades. Shakiba and Cristiana bring a special key to the table, and it is epigenetics. Tune in into our interview to learn more about: ◦ The founding story of Mitra Bio ◦ The role of genetic and epigenetic factors in skin health ◦ Cracking epigenetic code ◦ Role of reliable models in understanding skin diseases ◦ Skin aging and personalized approaches to reverse it ◦ The future of personalized skincare ◦ Advice to young biotech entrepreneurs from Shakiba and Cristiana…

Personalized Medicine Podcast

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Ep#041: Exploring Microgravity for Life Science with Daniela Bezdan 35:18

acum 3 years35:18

35:18

Welcome to the next episode of the Personalized Medicine Podcast. In this episode, we have talked about a variety of topics ranging from exploring space and microgravity for applications in biotechnology and physical science to developing pathogen detection systems. Our guest today is Dr. Daniela Bezdan, the Chief Scientific Officer of Yuri Gravity and co-founder of Poppy. Daniela is also the co-chair at several space-associated organizations such as ISSOP (International Space Standards Operation Procedure) and NASA GeneLabs that foster international cooperation, and support educational citizen science projects. Together with Daniela we discussed: ◦ Evolution of microgravity in biotech ◦ Yuri Gravity and its space mission ◦ Key factors in designing space biotech experiments ◦ Poppy and its pathogen detection system ◦ Challenges of starting a start-up ◦ Advice to budding biotech entrepreneurs ◦ The outlook on the next decade of personalized medicine Get in touch with Daniela: ◦ LinkedIn: Daniela Bezdan ◦ Twitter: @Daniela_Bezdan, @yurigravity, @poppy_health ◦ Web: https://www.yurigravity.com/ , https://poppy.com/…

Personalized Medicine Podcast

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Ep#040: Eliminating Cancer Using Invariant Natural Killer T Cells (iNKTs) with Dr. Jennifer Buell 53:29

acum 3 years53:29

53:29

Welcome to the next episode of the Personalized Medicine Podcast. On this podcast we have talked extensively about antibody, vaccine and CAR-T cell based approaches to treat cancer. Today we will be talking about a new approach in oncology that is based on invariant Natural Killer T Cells, or iNKTs. Our guest today is Dr. Jennifer Buell, the founder, CEO and President of MiNK Therapeutics and the former President and COO of Agenus. Jennifer has over 25 years of experience in the biopharmaceutical space, having held multiple leadership positions at biotech companies. In her tenure at Agenus, she transformed a neoantigen vaccine development startup into a multifaceted company with a strong global footing. She is now leading MiNK therapeutics, the precision oncology company that develops targeted iNKT cells for treatment of various types of cancer and autoimmune diseases. Together with Jennifer we discussed: ◦ Evolution of immunooncology over the the last two decades ◦ Role of immune system in fighting cancer ◦ Neoantigen vaccines as a tool for personalized cancer treatment ◦ Invariant Natural Killer T Cells (iNKTs) and their role in combating cancer ◦ Advantage of iNKTs over other cancer treatments ◦ Potential of combination therapies in oncology ◦ Challenges in bringing novel cell-based therapies to the market ◦ Advice to budding biotech entrepreneurs ◦ The outlook on the next decade of cancer treatment Get in touch with Jennifer: LinkedIn: Jennifer S. Buell Twitter: @jbuell01 Web: https://minktherapeutics.com/…

Personalized Medicine Podcast

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Ep#039: Using Protein Degraders to Treat Neurodegenerative Diseases with Dr. Beth Hoffman 34:43

acum 3 years34:43

34:43

In this episode we dive deep again into the topic of protein degradation and how it can be leveraged to treat neurodegenerative diseases. Our guest today is Dr. Beth Hoffman, the founder, CEO and President to Origami Therapeutics. Beth's career is a showcase of remarkable success in the biotech industry. She spent almost 25 years working in CNS drug discovery and was involved in the development of over 30 therapeutic molecules. Most notably she led the discovery and development of a few first-in-class blockbuster drugs for cystic fibrosis at Vertex Pharmaceuticals. Her most recent venture, Origami Therapeutics, is focusing on developing protein degraders aiming at neurodegenerative disorders and, specifically, Huntington’s Disease. Together with Beth we discussed: ◦ The evolution of drug discovery & development over the last 30 years ◦ How protein degraders work ◦ Role of protein structure prediction algorithms in therapy design ◦ Possibility of using targeted protein degradation for treatment of Huntington’s diseases ◦ Differences between treating familial vs sporadic neurodegenerative disorders ◦ The future of personalized medicine ◦ Actionable advice for young biotech entrepreneurs Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com…

Personalized Medicine Podcast

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Special Episode: Ukraine 5:48

acum 3 years5:48

5:48

Thank you very much for tuning into this special episode of the Personalized Medicine Podcast. Some of you might know that our founder and host Oleksandr (a.k.a. Sasha) is Ukrainian. In this difficult moment for his country, Sasha shares his thoughts on current situation in Ukraine and explains how anyone in the world can help and support people of Ukraine and its scientific community. Out team has prepared a list of trusted organizations and charitable foundations supporting Ukraine at the moment: Support Ukrainian military (Official Bank Account of Ukrainian Ministry of Defense): https://bit.ly/35Kl4Gy Humanitarian aid organizations providing aid for Ukrainians affected by war: ◦ Ukraine Humanitarian Fund managed by United Nations https://crisisrelief.un.org/t/ukraine - The Ukraine Humanitarian Fund is one of the UN's country-based pooled funds. Contributions are collected into a single, unearmarked fund and managed locally under UN leadership. As crises evolve, funds are made directly and immediately available to a wide range of partner organizations at the front lines of response. This way, funding reaches the people most in need when they need it ◦ Voices of Children - https://voices.org.ua/en/ - Charitable Foundation Voices of Children helps children affected by the war in (eastern) Ukraine. They provide psychological and psychosocial support to children. It helps them overcome the consequences of armed conflict ◦ Vostok-SOS - https://vostok-sos.org/en/ - Non-profit organization focused on comprehensive assistance to conflict-affected persons and IDPs, promoting democratic transformation and human rights values in Ukraine If you would like to host a refugee, you can register at one of the following platforms: ◦ https://www.eu4ua.org/ ◦ https://www.unterkunft-ukraine.de/ ◦ https://www.ukraineshelter.com/en/ The global list of research groups and labs that are supporting Ukrainian scientists. Feel free to add your group or share this list with fellow Ukrainian scientists in need of help: https://docs.google.com/spreadsheets/d/1HqTKukfJGpmowQnSh4CoFn3T6HXcNS1T1pK-Xx9CknQ/edit?usp=sharing Thank you very much for your support! You are awesome! Stay safe Peace…

Personalized Medicine Podcast

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Ep#038: Unleashing the full power of CAR-T cells with Dr. Eric von Hofe 34:16

acum 3 years34:16

34:16

In this episode we are returning to a very exciting topic of immunooncology and we will talk in detail about novel approaches to treat cancer, based on CAR-T cell technology. Please welcome Dr. Eric von Hofe, the Senior Advisor and former President of Affyimmune Therapeutics. Eric’s story is a showcase of a remarkable career in the biotech industry. Eric studied Biology at UC Berkeley and received his PhD from the University of Southern California. HEric continued his career in cancer research doing two PostDocs at ETH Zurich and Harvard and then taking a position of Assistant Professor at the University of Massachusetts Medical School. In 1992 Eric made a transition to the biopharmaceutical industry leading the development of antisense oligonucleotide therapies at Hybridon. Eric subsequently led multidisciplinary drug development programs at Millennium Pharmaceuticals as a Director of Drug Discovery Research. Eric has been fundamental for two prominent immuno-oncology companies: Antigen Express, a company focusing on peptide-based cancer vaccines; and Affyimmune Therapeutics, a biotech startup developing novel approaches for CAR-T cell based therapies. With about 50 articles in peer-reviewed journals and four patents Eric is a true expert in the field of oncology Together with Eric we discussed: Differences between career in academia and industry Evolution of therapeutic landscape in oncology over the last 30 years Role of immunology in development of novel cancer therapies CAR-T cells and their role in combating cancer Affinity tuning of CAR-T cells as mechanism to decrease off-target effect Cancer vaccines: peptide vs mRNA The future of immunooncology Get in touch with Eric: LinkedIn: https://www.linkedin.com/in/ericvonhofe/ Email: evhlfe@gmail.com Web: https://affyimmune.com/ Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com…

Personalized Medicine Podcast

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Ep#037: Making Personalized Medicine Available to Every Patient with Christopher Wells 32:18

acum 3 years32:18

32:18

Welcome to the next episode of the Personalized Medicine Podcast. On this show we typically talk about science and technology driving the progress in personalized medicine. But the policy side of things and patient access are equally important. We are happy to welcome on our podcast Christopher Wells, the Vice President of Public Affairs at the Personalized Medicine Coalition. Chris has recently published an article in STAT in which he eloquently described why we cannot narrow down personalized medicine just to cancer and need to look at it through a larger lens. And this is what we have discussed with Chris in this interview. Tune in to this episode to learn more about: Personalized Medicine beyond #genomics and #cancer What is the Personalized Medicine Coalition and what are its goals? Difficulties and success stories of bringing healthcare stakeholders together The role of government in driving personalized medicine agenda Role of physician education in implementation of personalized medicine approaches Generation of reliable clinical data to support personalized medicine implementation Challenge of equal patient access to personalized therapies The outlook on the future of personalized medicine Get in touch with Chris: LinkedIn: Christopher Wells, M.P.A. Twitter: @permedcoalition Web: https://www.personalizedmedicinecoalition.org/ Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com…

Personalized Medicine Podcast

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Ep#036: Tackling Sepsis Using Next Generation Sequencing with Dr. Philip Stevens 34:31

acum 3 years34:31

34:31

Welcome to Season 3 of the Personalized Medicine Podcast! We hope you all head a good start in 2022 and are ready to dive deep into the world of personalized medicine with us again. In this first episode of Season 3, we address a very important and, frankly speaking, underappreciated topic of sepsis, commonly known as bacterial blood poisoning. Did you know that last year, sepsis killed more people than 5 most common types of cancer combined? For this episode, our host Oleksandr Yagensky sat down with the co-founder and CEO of Noscendo, Dr. Philip Stevens. Philip and his team are developing diagnostic workflows based on detection of bacterial and fungal cell-free DNA from blood to detect infections. Listen to this episode to learn more about: ◦ The founding story of Noscendo ◦ Building a successful diagnostics startup in Europe ◦ Generation of clinical evidence for early stage startups ◦ Misconceptions about sepsis and sepsis diagnostics ◦ How NGS can help detect sepsis early ◦ Role of DNA sequencing in determining antibiotic resistance ◦ Philip’s advice to aspiring life science entrepreneurs Get in touch with Philip: ◦ LinkedIn: https://www.linkedin.com/in/philip-stevens-4ab68213b/ ◦ Twitter: https://twitter.com/noscendo ◦ Web: https://noscendo.com/ Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com…

Personalized Medicine Podcast

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2021 in Personalized Medicine: Crossover Episode with the Host of the Genetics Podcast, Dr. Patrick Short 57:09

acum 3 years57:09

57:09

Welcome to the final episode of 2021! This one was long in the making. We are happy to present the crossover episode between the Genetics Podcast and the Personalized Medicine Podcast. In this episode our host Oleksandr (Sasha) Yagensky wraps up 2021 with one and only Patrick Short, the CEO of Sano Genetics and host of the Genetics Podcast. Listen to Patrick and Sasha as they share their 2021 highlights from the world of Personalized Medicine. Together with Patrick we focused on 6 highlights in 2021: ◦ Large scale liquid biopsy trial for presymptomatic cancer detection ◦ Whole genome sequencing making its entry into newborn screening programs for rare diseases ◦ Advances in application of autologous iPSCs for treatment of Parkinson’s disease ◦ Progress in one-time treatments to reverse genetic disorders ◦ Launch of the first FDA approved diagnostic test based on glycoprotein biomarkers for cancer detection ◦ Rise of AI in drug discovery & development Listen and let us know if you agree with our list? Which important 2021 event did we miss? Let us know on our Twitter or LinkedIn channels. Make sure to check the Genetics Podcast. Patrick is a fantastic host and puts together great interviews with the thought-leaders in the fields of personalized medicine, rare diseases and genetics research. Download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com…

Personalized Medicine Podcast

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Ep#034: Reversing Aging with Daniel Oliver 32:37

acum 3 years32:37