MODCAST podcast

51:38

Dr. Jamie Lo, an Associate Professor at Oregon Health & Science University, and Dr. Adam Crosland, an Assistant Professor at Oregon Health & Science University, discuss the risks of substance use, particularly cannabis, in pregnancy.

1
Dr. Victor Ambros and Dr. Gary Ruvkun on the Discovery of microRNA and More 1:32:14

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1:32:14

Winners of the 2024 Nobel Prize in Physiology or Medicine Dr. Victor Ambros and Dr. Gary Ruvkun give a rare, extended joint interview about the road that led them to their discovery of miRNA in a roundworm, Dr. Ruvkun’s later discovery of miRNA in humans, how the scientists were both inspired at a young age by astronomy, what Dr. Ambros’ late father might have said about his son’s Nobel win, and a decades-old story from Dr. Ruvkun about a trip to Bolivia.…

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Dr. Emre Seli and Jonathan Cherry on the 2024 Year in (Research) Review 44:59

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44:59

March of Dimes Chief Scientific Advisor Dr. Emre Seli and March of Dimes Senior Director of Research Operations Jonathan Cherry look back on MODCAST since its launch, and look forward to episodes in 2025.

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Dr. Sam Mesiano on the Enzyme Discovery that Could Revive Progesterone Therapy for Preterm Birth 1:17:50

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1:17:50

Dr. Sam Mesiano, an investigator at the March of Dimes Ohio Collaborative Prematurity Research Center, discusses the enzyme that leads to progesterone withdrawal and labor in cases of infection-related preterm birth - and how this enzyme discovery can be used to revive progesterone therapy to delay or stop preterm birth.…

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Dr. Alexiane Decout and Dr. David MacIntyre on the Protective Power of a Good Vaginal Microbiome 1:04:37

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1:04:37

Dr. Alexiane Decout, an assistant professor in immunology at the University of Warwick, and Dr. David MacIntyre, one of the directors of the March of Dimes Prematurity Research Center at Imperial College London, discuss the biological advantage of Lactobacillus Crispatus, the most in-demand of all vaginal microbiome bacteria, which is protective against preterm birth. Read the preprint here: https://www.biorxiv.org/content/10.1101/2024.09.13.612838v1.full…

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Jonathan Cherry on March of Dimes Research Grants and Awards 57:48

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57:48

March of Dimes Senior Director of Research Operations Jonathan Cherry on March of Dimes research grants and awards.

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Dr. Sarah England and Dr. Nima Aghaeepour on How Sleep and Movement May Lower Preterm Birth Risk 38:20

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38:20

Dr. Nima Aghaeepour, an investigator at the March of Dimes Prematurity Research Center at Stanford, and Dr. Sarah England, the director of the Center for Reproductive Health Sciences at Washington University School of Medicine, discuss a new Artificial Intelligence (AI) model that found that sleepers and movers have a 52% reduced risk of delivering early while those sleeping and moving less have a 44% increased risk of delivering early.…

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March of Dimes' 2024 Basil O'Connor Award Winners Dr. Enninga and Dr. Murray Horwitz on Cell Free (cf) Fetal DNA as Labor Trigger, Barriers to Postpartum Heart Health 1:03:20

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1:03:20

The 2024 winners of the March of Dimes Basil O'Connor Starter Scholar Research Awards, Dr. Elizabeth Enninga and Dr. Mara Murray Horwitz, discuss their areas of study. Dr. Enninga, an Assistant Professor of Obstetrics & Gynecology, and Immunology, at Minnesota’s Mayo Clinic, explains how cell free (cf) fetal DNA triggers labor and preterm birth, and how understanding more about this process can help prevent early labor and more effectively induce labor. Dr. Murray Horwitz, a primary care doctor at Boston Medical Center and an assistant professor of medicine at Boston University, discusses barriers women with a hypertensive disorder of pregnancy (HDP), like preeclampsia, face in achieving cardiac and overall health after childbirth, and delves into an intervention called patient navigation that can lessen those barriers.…

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Dr. Alan Flake on the Artificial Womb, Fetal Surgery, and Stem Cell Therapy 57:31

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57:31

Dr. Alan Flake, the Director of the Center for Fetal Research at the Children’s Hospital of Philadelphia and 2021 March of Dimes Prize recipient, discusses the most impactful pursuits of his career: fetal surgery, the artificial womb, and in utero stem cell therapy.

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Dr. Brice Gaudillière on Separating the Signal from the Noise: A Novel Biomarker Identification Model for Preterm Birth and Preeclampsia 1:02:28

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1:02:28

Dr. Brice Gaudillière, an investigator at the March of Dimes Prematurity Research Center at Stanford University, discusses a breakthrough Machine Learning (ML) algorithm that makes reliable predictions about labor onset, preterm birth, and preeclampsia and also identifies the biological markers supporting those predictions.…

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Dr. Marisa Bartolomei on Imprinted Genes, Epigenetic Mutations and Developmental Disorders 36:50

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36:50

Dr. Marisa Bartolomei, a University of Pennsylvania professor of cell and developmental biology, co-director of the university's Epigenetics Institute, and winner of the 2024 March of Dimes Richard B. Johnston, Jr., MD Prize, on discovering one of the first imprinted genes, making connections between imprinted gene mutations and developmental disorders, and uncovering the exact pathways of gene imprinting defects: namely, abnormalities in DNA methylation.…

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Dr. Jonas Miller on Unlocking the Connection of Maternal Stress and Child Brain Function 44:00

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44:00

Former Stanford PRC collaborator Dr. Jonas Miller, now a Psychological Sciences Assistant Professor at the University of Connecticut, discusses how the stress a woman experiences before pregnancy is associated with the way her child's brain functions around three to five years old. Those children, Dr. Miller found, have a harder time with impulse control.…

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Dr. Tim Hand on Breastmilk Antibodies and Necrotizing Enterocolitis (NEC) 45:31

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45:31

Dr. Tim Hand, a March of Dimes researcher at the University of Pittsburgh, discusses the link between breast milk and a life-threatening preterm birth-related condition called necrotizing enterocolitis (NEC). As it turns out, not all breast milk is protective against NEC.

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March of Dimes President Dr. Elizabeth Cherot on the Innovation Fund 46:54

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46:54

Dr. Elizabeth Cherot, the 6th and current President and CEO of March of Dimes, and the first medical doctor to lead the organization since its founding in 1938, discusses the March of Dimes Innovation Fund.

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Dr. Lynne Sykes on Understanding the Links Between Vaginal Microbiome and Preterm Birth 31:37

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