No Priors: Artificial Intelligence | Technology

40:32

This week on No Priors , Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Moderna. They explore how Flagship creates the conditions for scientific breakthroughs, tackles regulatory uncertainty, and pushes the boundaries of discovery. Noubar shares insights on AI’s role in healthcare, the challenges of bringing new therapies to market, and lessons learned from past pandemics. He also discusses Flagship’s platform approach to biotech innovation and introduces the idea of polyintelligence. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @NoubarAfeyan Show Notes: 0:00 Introduction 0:48 Founding Flagship 5:51 Fostering environments for emergence 11:17 Expanding into new frontiers 14:26 Developing technology amid regulatory uncertainty and risk 19:12 How Flagship has evolved 22:47 AI applications in healthcare 27:30 Bottlenecks in bringing new therapies to market 32:20 Lessons for the next pandemic 34:11 Building a platform 38:10 Polyintelligence…

No Priors: Artificial Intelligence | Technology | Startups

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Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute 57:40

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57:40

On this week’s episode of No Priors , Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Founder at Vevo Therapeutics; Johnny Yu, CSO/Co-Founder at Vevo Therapeutics; Patrick Hsu, CEO/Co-Founder at Arc Institute; Dave Burke, CTO at Arc Institute; and Hani Goodarzi, Core Investigator at Arc Institute. Predicting protein structure (AlphaFold 3, Chai-1, Evo 2) was a big AI/biology breakthrough. The next big leap is modeling entire human cells—how they behave in disease, or how they respond to new therapeutics. The same way LLMs needed enormous text corpora to become truly powerful, Virtual Cell Models need massive, high-quality cellular datasets to train on. In this episode, the teams discuss the groundbreaking release of the Tahoe-100M single cell dataset, Arc Atlas, and how these advancements could transform drug discovery. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @Nalidoust | @IAmJohnnyYu | @PDHsh | @Davey_Burke | @Genophoria Download the Tahoe Dataset Show Notes: 0:00 Introduction 1:40 Significance of Tahoe-100M dataset 4:22 Where we are with virtual cell models and protein language models 10:26 Significance of perturbational data 17:39 Challenges and innovations in data collection 24:42 Open sourcing and community collaboration 33:51 Predictive ability and importance of virtual cell models 35:27 Drug discovery and virtual cell models 44:27 Platform vs. single hypothesis companies 46:05 Rise of Chinese biotechs 51:36 AI in drug discovery…

No Priors: Artificial Intelligence | Technology | Startups

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Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company 38:14

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38:14

Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors . A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise, the autonomous vehicle company acquired by GM for $1 billion. Now he’s taking on AI-powered home robotics with The Bot Company. In this episode, Kyle shares his journey building transformative tech companies, the challenges of scaling autonomous systems, and why he believes home robots are the next frontier. They also discuss the parallels between AVs and robotics, overcoming consumer skepticism, US vs. China manufacturing, and the policies needed to foster a competitive robotics industry. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @KVogt Show Notes: 0:00 Introduction 0:29 Founding Cruise 3:12 Tesla vs. Waymo approach 4:44 Scaling autonomous vehicles 10:03 The Bot Company 16:35 Deploying robots in the home 17:56 Parallels between robots and AV markets 20:51 Personifying robots and overcoming consumer skepticism 25:00 Timeline on consumer robots 26:47 Chinese vs. US manufacturing 29:15 Fostering a competitive domestic robotics industry 34:00 Lessons from Cruise & personal philosophies…

No Priors: Artificial Intelligence | Technology | Startups

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How Harvey AI is Changing the Legal Industry with Winston Weinberg 49:35

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49:35

This week on No Priors, Sarah sits down with Harvey cofounder and CEO Winston Weinberg. Harvey is one of the leading application layer AI companies, building domain-specific AI for law firms, professional service providers, and the Fortune 500. They are already working with companies like Bridgewater, KKR, PWC, and O’Melveny with over $500M in funding from OpenAI, Sequoia, Kleiner, GV and Elad and Sarah. In this episode, Sarah and Winston cover AI product strategy, the future of professional services, company values, keeping up with research, and the law industry of the future. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @WinstonWeinberg Show Notes: 0:00 Introduction 2:39 Harvey’s founding story 3:46 Capability improvement 6:39 Building teams around AI capabilities 9:17 End to end task completion 12:37 Beginning with large industry leaders 17:21 Working with users skeptical of automation 20:40 Being a lawyer today and in the future 26:02 Adapting product for other domains 26:58 Hiring philosophy at Harvey 30:39 Lessons and mistakes as a founder 32:53 Personal drive 40:21 Advice to other founders 44:35 Prediction for next ChatGPT moment…

No Priors: Artificial Intelligence | Technology | Startups

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DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad 22:32

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22:32

This week on No Priors , Sarah and Elad celebrate the 100th episode! They dive into the biggest AI stories of 2025, breaking down DeepSeek—truth vs. hype, the rapid consumer adoption, and the real cost of training the models. They debate model commoditization and the value of being a frontier model provider vs. building on existing work. Plus, they unpack OpenAI’s new Deep Research release and the latest on Stargate. Finally, they share bold predictions for 2025, covering robots, autonomous vehicles, local AI models, emerging data-generation strategies, and reasoning breakthroughs. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil Show Notes: 0:00 Introduction 0:19 DeepSeek 5:38 Are models commoditizing? 8:33 DeepSeek’s consumer adoption 9:16 OpenAI’s Deep Research release 13:30 Stargate 15:04 Elad & Sarah’s Predictions for 2025…

No Priors: Artificial Intelligence | Technology | Startups

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Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward 27:11

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27:11

This week on No Priors, Elad sits down with Rick Caruso, LA real estate developer and runner-up in the 2022 mayoral race. With experience serving under three LA mayors, as well as on the police commission and the board of water and power, Rick offers a unique perspective on the systemic failures that contributed to the devastation of the January 2025 wildfires in communities like the Palisades and Altadena. He discusses the steps he took to build more resilient infrastructure in his properties and how California can rebuild smarter to better prepare for future disasters. They also explore the state’s water management, rising crime, and how to leverage California’s vast natural resources and budget to create a better future for all residents. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @RickCarusoLA Show Notes 0:00 Introduction 0:56 Caruso’s history in business and public service 3:36 Failures in fire prevention and response 5:58 How Caruso’s properties survived 8:26 Water shortages and infrastructure failures 9:47 Arson, looting, and crime in LA 15:03 Rebuilding 20:50 Allocating California’s resources effectively 26:15 Caruso’s future plans…

No Priors: Artificial Intelligence | Technology | Startups

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What Can We Do About Wildfires? With Convective Capital’s Bill Clerico 37:59

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37:59

This week on No Priors , Sarah and Elad sit down with Bill Clerico, founder of Convective Capital, an early stage venture fund focused on technology-driven solutions for wildfire mitigation and climate resilience. The wildfires in Los Angeles have caused unprecedented property damage and immense hardship for countless individuals and families. This episode is devoted to diving into understanding what happened and what we can do in the future. Bill shares his insights into the increasing severity of wildfires, the role of policy, and how infrastructure issues, like outdated building codes and underfunded utilities, are contributing to the crisis. They discuss the latest innovations in fire-fighting technology, from advanced detection to drones, and how these tools can help mitigate future damage. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @BillClerico Show Notes: 0:00 Introduction 1:02 Why are wildfires getting worse? 5:37 Policies and regulatory decisions 10:47 Housing: building codes and permitting 13:19 Key factors in response 16:20 Improving water supply and city infrastructure 19:10 Preventing wildfires 21:26 Underinvestment in California’s utilities 26:53 Innovative fire fighting technology 29:35 Accelerating Los Angeles’ recovery 34:29 Actions homeowners, insurance companies, and governments can take…

No Priors: Artificial Intelligence | Technology | Startups

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How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang 30:09

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30:09

Today on No Priors , co-founder and CEO of Decagon, Jesse Zhang, joins Elad to discuss the future of agentic customer support. Decagon provides AI-powered customer interactions for companies like Rippling, Notion, Duolingo, Classpass, Substack, Vanta, Eventbrite, and more. Jesse shares the thesis behind starting Decagon, why he sees customer support as the ideal entry point for agentic technology, and what areas of AI excite him most. They also discuss voice-based interfaces, issues with latency in current capabilities, and the connection between young math olympiad communities and today’s AI startups. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @TheJesseZhang Show Notes: 0:00 Introduction 0:30 Starting Decagon 3:15 Business impact of adopting agents for customer support and customer ops 8:00 AI infrastructure and models for customer success agents 12:05 Voice-based capabilities and text-to-speech engines 15:00 Combatting latency 16:25 Crossover of math and AI communities 21:12 Exciting areas of AI 25:29 Strengths and weaknesses of agents…

No Priors: Artificial Intelligence | Technology | Startups

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Erik Bernhardsson on Creating Tools That Make AI Feel Effortless 23:36

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23:36

Today on No Priors , Elad chats with Erik Bernhardsson, founder and CEO of Modal Labs, a platform simplifying ML workflows by providing a serverless infrastructure designed to streamline deployment, scaling, and development for AI engineers. Erik talks about his early work on Spotify’s ML algorithms, what Modal offers today, and his vision for building an end-to-end solution for AI engineers. They dive into GPU trends, cloud vs on-premise setups, and when to train custom models vs use off-the-shelf solutions. Erik also shares his thoughts on the evolving role of AI in fields like coding, physics, and music. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @Bernhardsson Show Notes: 0:00 Introduction 0:22 Erik's early interest in ML infra 1:22 Founding Modal Labs 4:17 State of GPU use today and what’s to come 7:14 Modal's end-to-end vision 9:00 Differentiating amongst competition 10:20 Cloud vs on-premise 12:35 Popular AI models 13:20 Gaps in AI infrastructure 14:55 Insights on vector databases 16:48 Training models vs off-the-shelf models 17:47 AI’s impact on coding and physics 22:14 AI's impact on music…

No Priors: Artificial Intelligence | Technology | Startups

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The Best of 2024 with Sarah Guo and Elad Gil 27:07

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2024 has been a year of transformative technological progress, marked by conversations that have reshaped our understanding of AI's evolution and what lies ahead. Throughout the year, Sarah and Elad have had the privilege of speaking with some of the brightest minds in the field. As we look back on the past months, we’re excited to share highlights from some of our favorite No Priors podcast episodes. Featured guests include Jensen Huang (Nvidia), Andrej Karpathy (OpenAI, Tesla), Bret Taylor (Sierra), Aditya Ramesh, Tim Brooks, and Bill Peebles (OpenAI’s Sora Team), Dmitri Dolgov (Waymo), Dylan Field (Figma), and Alexandr Wang (Scale). Want to dive deeper? Listen to the full episodes here: NVIDIA's Jensen Huang on AI Chip Design, Scaling Data Centers, and his 10-Year Bet No Priors Ep. 89 | With NVIDIA CEO Jensen Huang The Road to Autonomous Intelligence, With Andrej Karpathy from OpenAI and Tesla No Priors Ep. 80 | With Andrej Karpathy from OpenAI and Tesla Transforming Customer Service through Company Agents, with Sierra’s Bret Taylor No Priors Ep. 82 | With CEO of Sierra Bret Taylor OpenAI’s Sora team thinks we’ve only seen the "GPT-1 of video models" No Priors Ep.61 | OpenAI's Sora Leaders Aditya Ramesh, Tim Brooks and Bill Peebles Waymo’s Journey to Full Autonomy: AI Breakthroughs, Safety, and Scaling No Priors Ep. 87 | With Co-CEO of Waymo Dmitri Dolgov Designing the Future: Dylan Field on AI, Collaboration, and Independence No Priors Ep. 55 | With Figma CEO Dylan Field The Data Foundry for AI with Alexandr Wang from Scale No Priors Ep. 65 | With Scale AI CEO Alexandr Wang Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil Show Notes: 0:00 Introduction 0:15 Jensen Huang on building at data-center scale 4:00 Andrej Karpathy on the AI exo-cortex, model control, and a shift to smaller models 7:14 Bret Taylor on the agentic future of business interactions 11:17 OpenAI’s Sora team on visual models and their role in AGI 15:53 Waymo’s Dmitri Dolgov on bridging the gap to full autonomy and the challenge of 100% accuracy 19:00 Figma’s Dylan Field on the future of interfaces and new modalities 23:29 Scale AI’s Alexandr Wang on the journey to AGI 26:29 Outro…

No Priors: Artificial Intelligence | Technology | Startups

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Revolutionizing Customer Success with Agency’s Elias Torres 31:18

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Today on No Priors , Sarah sits down with Elias Torres, CEO and founder of Agency, an AI agent for customer success teams. Elias shares his journey from growing up in Nicaragua to founding several companies, leading engineering at HubSpot, and selling Drift for $1B. He also discusses his work consulting with OpenAI in 2022, which deepened his understanding of the business opportunity LLMs presented and inspired him to start Agency. In this episode, Elias offers a unique perspective on the future of AI and customer success, explaining how current software has fallen short and his vision for a new generation where customers have direct relationships, spend less time on tasks, and have software working invisibly on their behalf. They also discuss the evolving landscape of hiring as teams shrink, and Elias reveals his ambitious plan to reach $1B in revenue with fewer than 100 employees. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @EliasT Show notes: 0:00 Introduction 0:34 Elias’ journey to entrepreneurship 2:36 Growing HubSpot to IPO and founding Drift 6:19 Consulting with OpenAI, learning about LLMs, and diving into AI 9:35 Founding Agency to focus on customer success and AI-driven solutions 11:40 What will a customer experience look like in 5 years? 15:48 Company building in an era of AI, as a 5th time founder 18:32 Reducing headcount while raising the bar on hiring 20:35 Key challenges in building Agency and crafting a standout product 23:06 Addressing software flaws and transitioning to an era of intuitive, self-operating solutions 26:27 Timeline for the next-gen software revolution + the power of building from first principles…

No Priors: Artificial Intelligence | Technology | Startups

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How Diamond Cooling Could Power the Future of AI, with Akash Systems 42:21

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In this episode of No Priors, Sarah sits down with Felix Ejeckam and Ty Mitchell, founders of Akash Systems, a company pioneering diamond-based cooling technology for semiconductors used in space applications and large-scale AI data centers. Felix and Ty discuss how their backgrounds in materials science led them to tackle one of the most pressing challenges in tech today: thermal efficiency and heat management at scale. They explore how Akash is overcoming the limitations of traditional semiconductors and how their innovations could significantly boost AI performance. Felix and Ty also talk about their collaboration with India’s sovereign cloud provider, the importance of strengthening U.S. manufacturing in the AI chip market, and the role Akash Systems could play in advancing satellite technologies. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @AkashSystems | @FelixEjeckam Show Notes: 0:00 Introduction 0:30 What is Akash Systems? 2:12 Felix’s personal path to building Akash Systems 4:45 Ty’s approach to acquiring customers 6:40 Challenges of operating in space 7:54 Live demo on diamond’s conductivity 9:50 Heat issues in data centers 15:38 Heat as a fundamental limit to technological progress 20:44 Akash’s role in the semiconductor market 22:54 Growing diamonds 25:10 Collaborating with India’s sovereign cloud provider 28:15 Importance of American manufacturing for AI chips and outlook on current data capacity 29:45 The Chips Act 31:22 Future of national security lies in satellite and radar tech 32:46 Critical issues in the U.S. AI supply chain 36:34 Deep learning’s role in material science discovery 40:16 The future: AI expanding our possibilities…

No Priors: Artificial Intelligence | Technology | Startups

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Bolt’s Eric Simons on Enabling Everyone to Generate Websites with AI 38:17

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38:17

In this episode of No Priors , Sarah talks with Eric Simons, co-founder and CEO of StackBlitz. The company has experienced explosive growth since the launch 2 months ago of Bolt.new , an AI application that lets users prompt, run, edit, and deploy full-stack applications directly in the browser. Eric talks about the years-long journey that led to overnight success, why so many non-technical users are forming a community around Bolt, and the democratization of coding. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @EricSimons40 Show Notes: 0:00 Introduction 0:36 Bolt.new 2:04 How Bolt stands out from other coding assistants 3:28 Building beyond ChatGPT wrappers 6:13 Driving growth through community 9:42 Evals 13:29 Eric’s favorite use cases and startups leveraging Bolt 17:10 Why engineers are embracing no- code tools 24:32 The years long journey of StackBlitz 31:50 Balancing an Ironman, a newborn, and a product launch 35:18 Predictions for developers and code generation tools…

No Priors: Artificial Intelligence | Technology | Startups

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Model Plateaus and Enterprise AI Adoption with Cohere's Aidan Gomez 44:15

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44:15

In this episode of No Priors , Sarah is joined by Aidan Gomez, cofounder and CEO of Cohere. Aidan reflects on his journey to co-authoring the groundbreaking 2017 paper, “Attention is All You Need,” during his internship, and shares his motivations for building Cohere, which delivers AI-powered language models and solutions for businesses. The discussion explores the current state of enterprise AI adoption and Aidan’s advice for companies navigating the build vs. buy decision for AI tools. They also examine the drivers behind the flattening of model improvements and discuss where large language models (LLMs) fall short for predictive tasks. The conversation explores what the market has yet to account for in the rapidly evolving AI ecosystem, as well as Aidan’s personal perspectives on AGI—what it might look like and when it could arrive. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @AidanGomez Show Notes: 0:00 Introduction 0:36 Co-authoring “Attention is all you need” 2:27 Leaving Google and founding Cohere 4:04 Cohere’s mission and models 6:15 Pitfalls of current AI 8:14 How enterprises are deploying AI today 10:58 Build vs. buy strategy for AI tools 14:37 Barriers to enterprise adoption 20:04 Which types of companies should pretrain models? 24:25 Addressing flaws in open-source models 25:12 Current and expected progress in scaling laws 29:54 Advances in multi-step problem solving and reasoning 32:29 Key drivers behind the flattening curve of model improvements 36:25 Exploring AGI 39:59 Limitations of LLMs 42:10 What the market has mispriced…

No Priors: Artificial Intelligence | Technology | Startups

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AI and the Future of Math, with DeepMind’s AlphaProof Team 39:21

acum 16 weeks39:21