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Extrachromosomal circular DNA, chromosome evolution & circular DNA in human disease with the Regenberg Lab (Dr Birgitte Regenberg and Dr Sam Keating)
Manage episode 292387961 series 2859702
Content provided by Olivia Grant. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Olivia Grant or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.
In today's episode we speak to Dr Birgitte Regenberg and Dr Sam Keating from the Regenberg Lab, University of Copenhagen, about extrachromosomal circular DNA and it's significance in human disease.
Circular DNA originates from chromosomes but differs from linear chromosomes as they mostly don’t have centromeres - so if a gene is trapped on a circle, it can amplify its copy number to much above the normal 2 copies in a few cell cycles. If the gene is expressed, this means that much more protein is produced than it should be.
The Regenberg lab aims to understand how circular DNA is formed, maintained and how it affects the biology of the cell - thereby looking at eccDNA growth advantages or disadvantages in things such as aging and cancer.
Contact the lab here https://twitter.com/regenberg_lab
Find the labs website here https://www.regenberglab.net/
34 episoade
Distribuie
Manage episode 292387961 series 2859702
Content provided by Olivia Grant. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Olivia Grant or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.
In today's episode we speak to Dr Birgitte Regenberg and Dr Sam Keating from the Regenberg Lab, University of Copenhagen, about extrachromosomal circular DNA and it's significance in human disease.
Circular DNA originates from chromosomes but differs from linear chromosomes as they mostly don’t have centromeres - so if a gene is trapped on a circle, it can amplify its copy number to much above the normal 2 copies in a few cell cycles. If the gene is expressed, this means that much more protein is produced than it should be.
The Regenberg lab aims to understand how circular DNA is formed, maintained and how it affects the biology of the cell - thereby looking at eccDNA growth advantages or disadvantages in things such as aging and cancer.
Contact the lab here https://twitter.com/regenberg_lab
Find the labs website here https://www.regenberglab.net/
34 episoade
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Similar cu The Genomics Lab
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
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…
continue reading
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…
continue reading
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…
continue reading
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…
continue reading
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…
continue reading
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…
continue reading
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