We’ve all had a moment where we arrived at the grocery store and can’t remember passing any of the stoplights along the way. We’re halfway down an aisle and scrambling to remember what we even needed. Our mind is in overdrive trying to sort through our ever-growing to-do list. We’ve been there when just making it through the next task is hard. But the normal stresses of life aren’t the only thing YOU have to deal with. Nora McInerny hosts The Head Start: Embracing the Journey, a new podcast ...
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Iron: The Double-Edged Sword in Cancer
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Manage episode 366742389 series 3072470
Content provided by The Alpha Human Podcast. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The Alpha Human Podcast or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.
In this episode of the Alpha Human Podcast, Lawrence Rosenberg dives into the fascinating connection between iron overload and cancer. Iron is an essential micronutrient that plays a crucial role in various biological processes, including energy production, DNA synthesis, and immune system function. However, excess iron is also toxic and iron accumulation is typically seen in renal cell carcinoma (as well as other cancers), and increased iron metabolism is associated with the malignant transformation of cells, cancer progression, drug resistance, and immune evasion. In fact, individuals working in iron and steel occupations have a higher risk of developing kidney cancer. With that said, Lawrence also introduces a recently discovered form of programmed cell death called ferroptosis, which is induced by elevated intracellular iron levels and subsequent depletion of the antioxidant glutathione. Ferroptosis represents a natural mechanism to eliminate cancer cells, as well as those cells deficient in key nutrients or damaged by infection or ambient stress. While ferroptosis is beneficial in removing problematic cells, it should also be noted that dysregulation or excessive activation can contribute to disease pathogenesis, including neurodegenerative disorders. Interestingly, Lawrence highlights the unique characteristic of chromophobe renal cancer cells in having strikingly elevated levels of glutathione, which acts as a reactive oxygen species scavenger that protects these cells from ferroptosis. And although this metabolic dependency on glutathione enables chromophobe renal cell carcinoma (as well as a number of other cancers) to survive despite iron overload and oxidative stress, it may also turn out to be cancer's Achilles heal. 'Ferroptosis, a new form of cell death: opportunities and challenges in cancer': https://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0720-y 'Study uncovers novel treatment for chromophobe renal cell carcinoma': https://www.news-medical.net/news/20220620/Study-uncovers-novel-treatment 'Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency': https://www.pnas.org/doi/10.1073/pnas.2122840119 'Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas': https://www.biorxiv.org/content/10.1101/649046v1.full 'The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139531/ 'Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160331/ 'Iron metabolism: State of the art in hypoxic cancer cell biology': https://www.sciencedirect.com/science/article/pii/S0003986122000844 'Iron accumulation typifies renal cell carcinoma tumorigenesis but abates with pathological progression, sarcomatoid dedifferentiation, and metastasis': https://www.frontiersin.org/articles/10.3389/fonc.2022.923043/full#B39 'Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815535/#B101 'The Two Faces of Reactive Oxygen Species in Cancer': https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-041916-065808 Disclaimer: The content of this podcast, and any information, advice, opinions or statements within it are not intended, and are not to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not disregard or delay in obtaining medical advice for any medical condition you may have, and you should seek the assistance of a healthcare professional for any such conditions, and always inform your doctor of any changes you make, or are thinking about making to your lifestyle.
…
continue reading
60 episoade
MP3•Pagina episodului
Manage episode 366742389 series 3072470
Content provided by The Alpha Human Podcast. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The Alpha Human Podcast or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.
In this episode of the Alpha Human Podcast, Lawrence Rosenberg dives into the fascinating connection between iron overload and cancer. Iron is an essential micronutrient that plays a crucial role in various biological processes, including energy production, DNA synthesis, and immune system function. However, excess iron is also toxic and iron accumulation is typically seen in renal cell carcinoma (as well as other cancers), and increased iron metabolism is associated with the malignant transformation of cells, cancer progression, drug resistance, and immune evasion. In fact, individuals working in iron and steel occupations have a higher risk of developing kidney cancer. With that said, Lawrence also introduces a recently discovered form of programmed cell death called ferroptosis, which is induced by elevated intracellular iron levels and subsequent depletion of the antioxidant glutathione. Ferroptosis represents a natural mechanism to eliminate cancer cells, as well as those cells deficient in key nutrients or damaged by infection or ambient stress. While ferroptosis is beneficial in removing problematic cells, it should also be noted that dysregulation or excessive activation can contribute to disease pathogenesis, including neurodegenerative disorders. Interestingly, Lawrence highlights the unique characteristic of chromophobe renal cancer cells in having strikingly elevated levels of glutathione, which acts as a reactive oxygen species scavenger that protects these cells from ferroptosis. And although this metabolic dependency on glutathione enables chromophobe renal cell carcinoma (as well as a number of other cancers) to survive despite iron overload and oxidative stress, it may also turn out to be cancer's Achilles heal. 'Ferroptosis, a new form of cell death: opportunities and challenges in cancer': https://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0720-y 'Study uncovers novel treatment for chromophobe renal cell carcinoma': https://www.news-medical.net/news/20220620/Study-uncovers-novel-treatment 'Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency': https://www.pnas.org/doi/10.1073/pnas.2122840119 'Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas': https://www.biorxiv.org/content/10.1101/649046v1.full 'The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139531/ 'Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160331/ 'Iron metabolism: State of the art in hypoxic cancer cell biology': https://www.sciencedirect.com/science/article/pii/S0003986122000844 'Iron accumulation typifies renal cell carcinoma tumorigenesis but abates with pathological progression, sarcomatoid dedifferentiation, and metastasis': https://www.frontiersin.org/articles/10.3389/fonc.2022.923043/full#B39 'Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis': https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815535/#B101 'The Two Faces of Reactive Oxygen Species in Cancer': https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-041916-065808 Disclaimer: The content of this podcast, and any information, advice, opinions or statements within it are not intended, and are not to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not disregard or delay in obtaining medical advice for any medical condition you may have, and you should seek the assistance of a healthcare professional for any such conditions, and always inform your doctor of any changes you make, or are thinking about making to your lifestyle.
…
continue reading
60 episoade
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