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Inhale, Exhale, Repeat: Understanding COPD
Manage episode 422848766 series 3555208
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In today's episode, we delve into Chronic Obstructive Pulmonary Disease (COPD), a debilitating lung condition affecting millions worldwide. Characterized by obstructed airflow, COPD's symptoms—ranging from persistent cough and phlegm to life-threatening exacerbations—stem from the progressive degradation of lung structure. This disease is exacerbated by factors like smoking, air pollution, and exposure to occupational hazards like dust and chemicals. With a look at the lung's anatomy, from the macroscopic airways down to the microscopic alveoli, we explore how chronic inflammation and emphysema reduce lung function over time, making every breath a challenge. We also cover strategies to mitigate damage and manage symptoms, offering hope for improved quality of life through better disease management and potential advances in medical treatments.
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References:
Adeloye, D., Chua, S., Lee, C., Basquill, C., Papana, A., Theodoratou, E., ... & Global Health Epidemiology Reference Group (GHERG. (2015). Global and regional estimates of COPD prevalence:
Systematic review and meta–analysis. Journal of global health, 5(2). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693508/
Alagha, K., Palot, A., Sofalvi, T., Pahus, L., Gouitaa, M., Tummino, C., ... & Chanez, P. Íp(2014). Long-acting muscarinic receptor antagonists for the treatment of chronic airway diseases. Therapeutic advances in chronic disease, 5(2), 85-98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926345/
GOLD, 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD). (2023). 2023 Report: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. https://goldcopd.org
Rabe, K. F., Martinez, F. J., Ferguson, G. T., Wang, C., Singh, D., Wedzicha, J. A., ... & Dorinsky, P. (2020). Triple inhaled therapy at two glucocorticoid doses in moderate-to-very-severe COPD. New England Journal of Medicine, 383(1), 35-48. https://www.nejm.org/doi/10.1056/NEJMoa1916046
Suki, B., Stamenovic, D., & Hubmayr, R. (2011). Lung parenchymal mechanics. Comprehensive Physiology, 1(3), 1317. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929318/
CDC & National Center for Health Statistics. (May 2, 2024). Leading causes of death. https://www.cdc.gov/nchs/fastats/leading-causes-of-death.ht
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