What Is Chronic Kidney Disease?

ENCORE Research Group

Delve into the intricate world of kidney function and the complexities of chronic kidney disease (CKD) in our latest episode, where we unravel the fascinating mechanisms behind how kidneys filter blood several times a day. From nephrons to glomeruli and podocytes, we explore the vital role played by these microscopic structures. With over 13% of the global population affected, including 37 million Americans, CKD poses a significant public health challenge, progressing silently in its early stages and wreaking havoc on health, particularly the cardiovascular system, in advanced cases. Unraveling the causes of CKD reveals a mix of modifiable and non-modifiable risks, from diabetes and high blood pressure to age and family history. Ongoing research explores strategies to mitigate cardiovascular risks associated with CKD, from anticoagulants to managing inflammation and albumin levels. Join us as we navigate the complexities of chronic kidney disease, shedding light on the latest advancements in its management and gaining a newfound appreciation for the unsung heroes within us – our kidneys.
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References:
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Chen, T. K., Knicely, D. H., & Grams, M. E. (2019). Chronic kidney disease diagnosis and management: a review. Jama, 322(13), 1294-1304. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015670/

Lin, L., Tan, W., Pan, X., Tian, E., Wu, Z., & Yang, J. (2022). Metabolic syndrome-related kidney injury: A review and update. Frontiers in Endocrinology, 13, 904001. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.904001/full

National institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health. (October, 2016). Chronic Kidney Disease. U.S. Department of Health and Human Services https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd

Puy, C., Rigg, R. A., & McCarty, O. J. (2016). The hemostatic role of factor XI. Thrombosis research, 141, S8-S11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135087/

Romagnani, P., Remuzzi, G., Glassock, R., Levin, A., Jager, K. J., Tonelli, M., ... & Anders, H. J. (2017). Chronic kidney dis