Artwork

Content provided by by SC Zoomers and By SC Zoomers. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by by SC Zoomers and By SC Zoomers or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.
Player FM - Aplicație Podcast
Treceți offline cu aplicația Player FM !

Alzheimer Pivot: Increasing Amyloid Beta 42

14:10
 
Distribuie
 

Manage episode 455123405 series 3602245
Content provided by by SC Zoomers and By SC Zoomers. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by by SC Zoomers and By SC Zoomers or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.

Send us a text

Today we dive into groundbreaking research shaking up the foundations of Alzheimer’s disease (AD) theories! We’re challenging the long-held amyloid cascade hypothesis and uncovering exciting new insights that could change the way we think about and treat this complex condition.

For decades, the amyloid cascade hypothesis has dominated AD research, positing that the buildup of amyloid plaques is the main culprit behind cognitive decline. But recent studies reveal a compelling alternative: the proteinopenia hypothesis suggests that it's actually the depletion of soluble amyloid-beta 42 (Aβ42) that drives cognitive impairment. We’ll explore how this shift in perspective could revolutionize treatment strategies!

Get ready to hear about the latest findings from a comprehensive study analyzing data from nearly 26,000 AD patients. Discover how increases in cerebrospinal fluid Aβ42 levels are linked to significant cognitive improvements, while traditional approaches targeting plaque removal have often fallen short. Dr. Alberto Espay, leading the charge in this research, shares his insights on why boosting Aβ42 levels may hold the key to slowing cognitive decline.

We’ll discuss the implications of these findings for future research and treatment options, including the potential for new monoclonal antibody drugs that increase Aβ42 without the risks associated with plaque removal. This episode is filled with thought-provoking quotes and ideas that challenge conventional wisdom and inspire hope for those affected by Alzheimer’s.

Tune in as we unravel the complexities of AD, explore the innovative science behind these findings, and discuss what this means for the future of Alzheimer’s treatment. Let’s embark on this enlightening journey together and discover a new path towards understanding and combating cognitive decline!
Neuroscientists just turned a major Alzheimer’s theory on its head
https://www.psypost.org/neuroscientists-just-turned-a-major-alzheimers-theory-on-its-head/

Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer’s disease trials
https://academic.oup.com/brain/article/147/10/3513/7754406?login=false

Support the show

About SCZoomers:
https://www.facebook.com/groups/1632045180447285
https://x.com/SCZoomers
https://mstdn.ca/@SCZoomers
https://bsky.app/profile/safety.bsky.app

Spoken word, short and sweet, with rhythm and a catchy beat.
http://tinyurl.com/stonefolksongs
Curated, independent, moderated, timely, deep, gentle, evidenced-based, clinical & community information regarding COVID-19. Since 2017, it has focused on Covid since Feb 2020, with Multiple Stores per day, hence a large searchable base of stories to date. More than 4000 stories on COVID-19 alone. Hundreds of stories on Climate Change.
Zoomers of the Sunshine Coast is a news organization with the advantages of deeply rooted connections within our local community, combined with a provincial, national and global following and exposure. In written form, audio, and video, we provide evidence-based and referenced stories interspersed with curated commentary, satire and humour. We reference where our stories come from and who wrote, published, and even inspired them. Using a social media platform means we have a much higher degree of interaction with our readers than conventional media and provides a significant amplification effect, positively. We expect the same courtesy of other media referencing our stories.

  continue reading

102 episoade

Artwork
iconDistribuie
 
Manage episode 455123405 series 3602245
Content provided by by SC Zoomers and By SC Zoomers. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by by SC Zoomers and By SC Zoomers or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ro.player.fm/legal.

Send us a text

Today we dive into groundbreaking research shaking up the foundations of Alzheimer’s disease (AD) theories! We’re challenging the long-held amyloid cascade hypothesis and uncovering exciting new insights that could change the way we think about and treat this complex condition.

For decades, the amyloid cascade hypothesis has dominated AD research, positing that the buildup of amyloid plaques is the main culprit behind cognitive decline. But recent studies reveal a compelling alternative: the proteinopenia hypothesis suggests that it's actually the depletion of soluble amyloid-beta 42 (Aβ42) that drives cognitive impairment. We’ll explore how this shift in perspective could revolutionize treatment strategies!

Get ready to hear about the latest findings from a comprehensive study analyzing data from nearly 26,000 AD patients. Discover how increases in cerebrospinal fluid Aβ42 levels are linked to significant cognitive improvements, while traditional approaches targeting plaque removal have often fallen short. Dr. Alberto Espay, leading the charge in this research, shares his insights on why boosting Aβ42 levels may hold the key to slowing cognitive decline.

We’ll discuss the implications of these findings for future research and treatment options, including the potential for new monoclonal antibody drugs that increase Aβ42 without the risks associated with plaque removal. This episode is filled with thought-provoking quotes and ideas that challenge conventional wisdom and inspire hope for those affected by Alzheimer’s.

Tune in as we unravel the complexities of AD, explore the innovative science behind these findings, and discuss what this means for the future of Alzheimer’s treatment. Let’s embark on this enlightening journey together and discover a new path towards understanding and combating cognitive decline!
Neuroscientists just turned a major Alzheimer’s theory on its head
https://www.psypost.org/neuroscientists-just-turned-a-major-alzheimers-theory-on-its-head/

Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer’s disease trials
https://academic.oup.com/brain/article/147/10/3513/7754406?login=false

Support the show

About SCZoomers:
https://www.facebook.com/groups/1632045180447285
https://x.com/SCZoomers
https://mstdn.ca/@SCZoomers
https://bsky.app/profile/safety.bsky.app

Spoken word, short and sweet, with rhythm and a catchy beat.
http://tinyurl.com/stonefolksongs
Curated, independent, moderated, timely, deep, gentle, evidenced-based, clinical & community information regarding COVID-19. Since 2017, it has focused on Covid since Feb 2020, with Multiple Stores per day, hence a large searchable base of stories to date. More than 4000 stories on COVID-19 alone. Hundreds of stories on Climate Change.
Zoomers of the Sunshine Coast is a news organization with the advantages of deeply rooted connections within our local community, combined with a provincial, national and global following and exposure. In written form, audio, and video, we provide evidence-based and referenced stories interspersed with curated commentary, satire and humour. We reference where our stories come from and who wrote, published, and even inspired them. Using a social media platform means we have a much higher degree of interaction with our readers than conventional media and provides a significant amplification effect, positively. We expect the same courtesy of other media referencing our stories.

  continue reading

102 episoade

Alle Folgen

×
 
Loading …

Bun venit la Player FM!

Player FM scanează web-ul pentru podcast-uri de înaltă calitate pentru a vă putea bucura acum. Este cea mai bună aplicație pentru podcast și funcționează pe Android, iPhone și pe web. Înscrieți-vă pentru a sincroniza abonamentele pe toate dispozitivele.

 

Ghid rapid de referință