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The Black Death and Autoimmunity
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Was your psoriasis caused by the Black Death? Learn more than you might have wanted to know about the Black Death and delve into the data on the immunologic/autoimmune ramifications of wiping out nearly half of Europe.
· Intro 0:11
· In this episode 1:09
· The Black Death 1:24
· The History of IV Immunoglobulin episode 2:07
· How the Black Death happened 4:07
· How many people died from the Black Death? 6:49
· Record keeping 6:53
· The modern immune system, the Black Death and HIV 8:43
· What is CCR5? 8:55
· Current data on autoimmune diseases 10:35
· ERAP2 15:55
· How yersinia pestis kills you 21:04
· The inflammasome 22:03
· The Inflammasome for Dunces episode 22:09
· Mediterranean fever and mouse model 24:49
· Takeaways 30:20
· Summary 30:59
Disclosures: Brown reports no relevant financial disclosures.
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Wheelis M. Emerg Infect Dis. 2002;doi:10.3201/eid0809.100536.
Ratner D, et al. PLoS Pathog. 2016;doi:10.1371/journal.ppat.1006035.
Park YH, et al. Nat Immunol. 2020;doi:10.1038/s41590-020-0705-6.
Patin E. Nat Immunol. 2020;doi:10.1038/s41590-020-0724-3.
Galvani AP, et al. Proc Natl Acad Sci USA. 2003;doi:10.1073/pnas.2435085100.
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